-
Penalized orthogonal-components regression for large p small n data
03 Mar. 2010 | Publications | Contributor(s): Min Zhang, Dabao Zhang
Here we propose a penalized orthogonal-components regression (POCRE) for large p small n data. Orthogonal components are sequentially constructed to maximize, upon standardization, their correlation t…
http://ccehub.org/resources/287
-
Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression
03 Mar. 2010 | Publications | Contributor(s): Min Zhang, Dabao Zhang
Genome-wide associations between single-nucleotide polymorphisms and clinical traits were simultaneously conducted using penalized orthogonal-components regression. This method was developed to ident…
http://ccehub.org/resources/285
-
Case-control genome-wide association study of rheumatoid arthritis from Genetic Analysis Workshop 16 using penalized orthogonal-components regression-linear discriminant analysis
03 Mar. 2010 | Publications | Contributor(s): Dabao Zhang, Min Zhang
Currently, genome-wide association studies (GWAS) are conducted by collecting a massive number of SNPs (i.e., large p) for a relatively small number of individuals (i.e., small n) and associations are…
http://ccehub.org/resources/283