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Predicting Patient-specific CRC Incidence from Polyp Prevalence
17 Jun 2008 | Teaching Materials | Contributor(s): Eric Sherer
Seminal work on CRC incidence modeling argued that the slope of the linear log-log CRC incidence with age implies that 6 or 7 somatic mutations are required for transformation to CRC. Subsequent modeling efforts have built on this theme by using models of linear, sequential transformations for …
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Visual Analytics for Cancer Care Engineering
29 Aug 2008 | Teaching Materials | Contributor(s): David S. Ebert
The Purdue University Regional Visualization and Analytics Center (PURVAC) presents a visual analytics tool for analyzing GCxGC TOF Mass Spectrometry data for metabolomics samples.
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A Hierarchical System Based Approach to Improving Cancer Care
29 Aug 2008 | Teaching Materials | Contributor(s): Ann Christine Catlin
The presentation title is "Developing a Hierarchical System Based Approach to Improving Cancer Care: Establishing an Indiana Prototype for Next-generation Colorectal Cancer Care".
The Cancer Care Engineering (CCE) hierarchy of projects proposes a methology for improving cancer care and directing …
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Protocol IUCRO-0221 for the Cancer Care Engineering Study
30 Sep 2008 | Teaching Materials | Contributor(s): Julie S. Nagel
Protocol IUCRO-0221 submitted to the Scientific Review Committee of the Indiana University Simon Cancer Center Institutional Review Board on February 28, 2008.
Gabi Chiorean, M.D.
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Introduction to Population Balance Modeling
02 Oct 2008 | Teaching Materials | Contributor(s): Eric Sherer
This presentation gives an overview of the role and applications of population balance (or structured) models in describing biological phenomenon. These models represent the continuum between purely empirical models and mechanistic models where details are often lumped into the structured …
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Example Computations for Ion Detection
17 Oct 2008 | Teaching Materials | Contributor(s): Zhenwen Zhao
The excel spreadsheet describes the lipidomics analysis process for negative and positive ion detection applied to five samples.
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Statistical Modeling of OMIC Data
30 Oct 2008 | Teaching Materials | Contributor(s): Min Zhang
This presentation describes the statistical modeling work of Professor Min Zhang. A discussion of statistical methods for identifying biomarkers is presented first, including Classical methods and Bayesian and Regularized Variable Selection methods. Next, the alignment of GCxGC MS data using the …
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cceHUB: A Knowledge Discovery Environment for Cancer Care Engineering Research
19 Nov 2008 | Teaching Materials | Contributor(s): Ann Christine Catlin
Ann Christine Catlin presented this overview of cceHUB.org (powered by the HUBzero™ platform) at the first HUBzero™ Workshop.
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Building a Data Support Infrastructure for the Cancer Care Engineering OMIC Study
10 Apr 2009 | Teaching Materials | Contributor(s): Ann Christine Catlin
OMIC profiles hold enormous promise for transforming our understanding of biological processes and revealing the underlying biological mechanisms, especially the functional and interactive networks contributing to complex biological systems. Rapid advances in large scale OMIC analyses have produced …
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Cancer Care Engineering Colorectal Cancer : Rationale and Process
22 May 2010 | Teaching Materials | Contributor(s): Ann Christine Catlin
Sample Acquisition and Management team leader Gabriela Chiorean, M.D. presents the rationale and process for cancer care engineering of colorectal cancer.
Perform "omics" analysis of healthy, polyps, cancer samples
Compare analysis results between cancer, polyps and healthy: develop new …