Prelude Peptide Synthesizer Cleaning Instructions

22 Jan. 2009 | Publications | Contributor(s): Aaron Masavage

This document contains a lab Parker Lab specific preventative maintenance procedure for: 1. Cleaning after each Synthesis 2. Monthly Cleaning

Case-control genome-wide association study of rheumatoid arthritis from Genetic Analysis Workshop 16 using penalized orthogonal-components regression-linear discriminant analysis

03 Mar. 2010 | Publications | Contributor(s): Dabao Zhang, Min Zhang

Currently, genome-wide association studies (GWAS) are conducted by collecting a massive number of SNPs (i.e., large p) for a relatively small number of individuals (i.e., small n) and associations are made between clinical phenotypes and genetic variation one single-nucleotide polymorphism (SNP) at …

Simultaneous genome-wide association studies of anti-cyclic citrullinated peptide in rheumatoid arthritis using penalized orthogonal-components regression

03 Mar. 2010 | Publications | Contributor(s): Min Zhang, Dabao Zhang

Genome-wide associations between single-nucleotide polymorphisms and clinical traits were simultaneously conducted using penalized orthogonal-components regression. This method was developed to identify the genetic variants controlling phenotypes from a massive number of candidate variants. By …

Penalized orthogonal-components regression for large p small n data

03 Mar. 2010 | Publications | Contributor(s): Min Zhang, Dabao Zhang

Here we propose a penalized orthogonal-components regression (POCRE) for large p small n data. Orthogonal components are sequentially constructed to maximize, upon standardization, their correlation to the re-sponse residuals. A new penalization framework, implemented via empirical Bayes …