Nanospray LC/MS is well established as state-of-the-art technology because of its high sensitivity and low sample consumption. It is most often used for applications with limited sample amounts or when there is a need for analysis of trace level components in complex mixtures. Although nanospray LC/MS provides very high sensitivity, the use of multiple small capillary tubing connections and frequent clogging or leaking at the columns and nanospray needle make it challenging to implement and maintain. The Agilent HPLC-Chip/MS system solves these problems by integrating all of these components directly onto a reusable biocompatible polymer HPLC-Chip. Solvent and sample delivery to the chip, high pressure switching of flows and automated chip loading and positioning in the MS source are accomplished by the new HPLCChip Cube MS interface module.

If you reference this work in a publication, please cite as follows:

• (2009), "XCT PLUS: Agilent 1100 Series HPLC-Chip/MS System," http://ccehub.org/resources/214.

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1. global proteomics
2. XCT PLUS