Our lab uses chemical biology and proteomics to develop biosensors for intracellular phosphorylation signaling. We will use synthetic peptide and protein chemistry to design and synthesize probes for multiplexed analysis of cancer-related signaling proteins e.g. Abl, other Src-family kinases, receptor tyrosine kinases, etc. We will explore a wide variety of multidisciplinary analytical methods including mass spectrometry, fluorescence microscopy and flow cytometry to develop novel techniques for monitoring these signaling proteins and their activities. Our technology development goals will lead us to new methods for asking increasingly complex questions about multiple signaling activities, their disruption in cancer, and response of signaling profiles to cancer treatment.

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